PLATFORM
Brain Targeting Drug Delivery System (BDDSTM)
Our BDDS™ platform technology safely delivers a range of nucleic acid cargos, such as microRNA, siRNA, mRNA, and more, to all regions of the CNS. The proprietary platform, developed by BIORCHESTRA, fuses the core technologies of brain-targeted chemistry and RNA chemistry and is specifically formulated for IV administration.
BDDSTM Platform
Non-lipid nanoparticle carrier designed to efficiently and effectively deliver an API of choice, e.g., ASO, SSO, siRNA, mRNA, peptides, small proteins to all regions of the CNS
- Ligand amendment of polymer chains allows for preferential distribution to organ/tissue of choice, while the carrier provides longer-term stability in circulation
- Enabling convenient routes of administration: IV, others
- A favorable safety profile
PLATFORM
Our Nanomedicine in Action
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1. IV Administration
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2. BBB Penetration
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3. Endocytosis within Brain Cells
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4. Endosomal Escape
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5. Target Engagement
PLATFORM
Core Technologies
Blood-brain barrier crossing strategy
This platform targets a natural transporter for effective transcytosis of our drug-loaded nanoparticle carrier across the blood-brain barrier.
BIORCHESTRA-targeted transporter: Proprietary targeting leveraging our platform, so that drug-loaded nanoparticles cross the BBB and penetrate select cells through transporter-mediated transcytosis and endocytosis
Various RNA cargo encapsulation capabilities
The BDDS™ platform technology is a highly stable and safe brain delivery platform, enabling the encapsulation and delivery of various RNA drug cargos.
