Our Scientific Approach_pre
The interactions between microRNA (miRNA) and messenger RNA (mRNA) is essential to orchestrate protein expression
Genetic information encoded in DNA is transcribed to RNA, which is then translated to protein. The interactions between microRNA (miRNA) and messenger RNA (mRNA) constitute a transient set of information that cells use to elaborately orchestrate protein expression. Dysregulation of this interaction can induce disease conditions.
The miRNA features that control several targets are appropriate for multifactorial diseases like Alzheimer’s disease. And the miRNAs don’t affect the genome thus it’s not a permanent genetic effect. Also, it has minimal risk of side effects through the miRNA’s transient nature. Furthermore, this transient RNA therapy shows less immune reaction and toxicity in comparison with gene-based therapy and protein-based therapy.
We, at BIORCHESTRA, develop RNA-based therapeutics that can remedy such dysregulation. RNA-based therapeutics can be categorized by the mechanism of action. Gene delivery, noncoding RNAs, RNA editing, and Antisense oligonucleotides (ASOs) bind to nucleic acids; aptamers target proteins; mRNAs encode proteins. We design a strategy for drug delivery of a selected RNA modality using our proprietary drug delivery system (DDS).
Our R&D Strategy
An Integrated Approach to RNA Therapeutics
BIORCHESTRA uses fully integrated platforms for drug development. Our RNA modalities are loaded onto a proprietary delivery platform. The drug product is then complemented with a companion diagnostic; the biomarker-driven approach increases the clinical success rate.
Our goal is to change the therapeutic paradigm from treating the symptoms to providing fundamental cure for neurodegenerative diseases.